HCID 59017453, compound → HCID 59017445, compound

HRID 969705Notes

Reaction equation

HRID 969705 reaction equation
[CH3:1][C:2]1([CH3:32])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:31])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH:20][CH:21]([C:23]3[CH:28]=[CH:27][N:26]=[C:25]([NH:29][CH3:30])[N:24]=3)[CH3:22])=[CH:9][CH:10]=2)[CH2:5][NH:4][CH2:3]1>CCCCCC.CC(O)C>[CH3:32][C:2]1([CH3:1])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:31])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH:20][C@H:21]([C:23]3[CH:28]=[CH:27][N:26]=[C:25]([NH:29][CH3:30])[N:24]=3)[CH3:22])=[CH:9][CH:10]=2)[CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 1

HCID 59017453HCID 59017453, compound

Product 1

HCID 59017445HCID 59017445, compound

Reagents, catalysts & solvents 1

HCID 21585144Isopropanol hexaneSolvent

Procedure

N-(4,4-Dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-[1-(2-methylamino-pyrimidin-4-yl)-ethylamino]-benzamide (190 mg, 0.44 mmol) was separated on a chiral column (Chiralcel AD, 250×4.6 (mm) 10u, n-Hexane/i-PrOH/0.2% DEA (70:30), 1 mL/min). The (S) enantiomer was isolated. MS m/z: 431.3 (M+H). Calc'd. for C25H31N6O-431.55.

Sources & evidence

ORD record
ord-66061308318d4e179058d6fc116cbb0e
Source dataset
uspto-grants-2007_12
Patent number
US07307088B2

Reaction notes

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