Dimethylformamide dimethyl acetal → HCID 74015821, compound

HRID 969730Notes

Reaction equation

HRID 969730 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([Cl:10])=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13].CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([Cl:10])=[N:6][N:5]2[C:11]=1[S:12]([N:15]=[CH:18][N:19]([CH3:21])[CH3:20])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 14422383HCID 14422383, compound

Product 1

HCID 74015821HCID 74015821, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2,6-Dichloroimidazo[1,2-b]pyridazin-3-ylsulfonamide (2.00 g, 6.22 mmol) and N,N-Dimethylformamide dimethyl acetal (1.80 ml, 13.5 mmol) were heated under reflux for 4 hours in toluene (20.0 ml). The resulting reaction solution was left to cool to room temperature, and concentrated to dryness under reduced pressure to give the title compound as pale yellow crystals. The yield was 2.36 g (100%).

Workup

  1. customThe resulting reaction solution
  2. waitwas left
  3. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-995eaf41e8404746bb2c92b5623e7e9d
Source dataset
uspto-grants-2007_12
Patent number
US07307165B2

Reaction notes

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