反应详情

6-Chloro-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide (1.70 g, 5.65 mmol) was suspended in toluene (10.0 ml), and N,N-dimethylformamide dimethyl acetal (90%, 1.84 ml, 12.4 mmol) was added thereto and stirred for 3.5 hours under reflux. The reaction mixture was concentrated under reduced pressure. To the residue concentrated was added diisopropyl ether, and the crystals were collected by filtration to give the title compound as brown crystals. The yield was 1.96 g (97.4%).

1. temperatureunder reflux
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. concentrationTo the residue concentrated
4. additionwas added diisopropyl ether
5. filtrationthe crystals were collected by filtration