HCID 131726713, compound → HCID 178439348, compound

HRID 969743Notes

Reaction equation

HRID 969743 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.O=[C:8]([C:16]([F:19])([F:18])[F:17])[CH:9]([CH2:13][CH2:14][CH3:15])[C:10]([O-])=[O:11]>C(N(CCCC)CCCC)CCC>[OH:11][C:10]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[C:8]([C:16]([F:17])([F:18])[F:19])[C:9]=1[CH2:13][CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 131726713HCID 131726713, compoundHCID 178418311HCID 178418311, compound

Product 1

HCID 178439348HCID 178439348, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 7622TributylamineSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 14 g (0.17 mol) 3-amino-1,2,4-triazole, 38.4 g (0.17 mol) of 3-oxo-2-propyl-4,4,4-trifluorobutanoate and 50 ml of tributylamine were stirred at 180° C. for 6 h. Work-up was carried out analogously to Ex. 1. Drying gave 33 g (0.13 mol) of the title compound.

Workup

  1. customDrying

Sources & evidence

ORD record
ord-f2959bdde0c14497a8165c42b2ca7811
Source dataset
uspto-grants-2007_12
Patent number
US07307172B2

Reaction notes

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