Cyclopentylamine → HCID 59017635, compound

HRID 969744Notes

Reaction equation

HRID 969744 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:15]1[N:20]2[N:21]=[CH:22][N:23]=[C:19]2[N:18]=[C:17]([C:24]([F:27])([F:26])[F:25])[C:16]=1[CH2:28][CH2:29][CH3:30]>C(Cl)Cl>[CH:1]1([NH:6][C:15]2[N:20]3[N:21]=[CH:22][N:23]=[C:19]3[N:18]=[C:17]([C:24]([F:26])([F:27])[F:25])[C:16]=2[CH2:28][CH2:29][CH3:30])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 2906CyclopentylamineHCID 8471TriethylamineHCID 59017634HCID 59017634, compound

Product 1

HCID 59017635HCID 59017635, compoundYield 82.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

With stirring, a mixture of 0.13 g (1.5 mmol) of cyclopentylamine and 0.15 g (1.5 mmol) of triethylamine in 10 ml of methylene chloride was added to a mixture of 0.40 g (1.5 mmol) of 7-chloro-6-propyl-5-trifluoromethyl-[1,2,4]-triazolo-[1,5-α]-pyrimidine (cf. Ex. 5) in 20 ml of methylene chloride. The reaction mixture was stirred at room temperature for 16 h, work-up was carried out analogously to Ex. 3. This gave 0.39 g (1.24 mmol) of the title compound (melting point 179° C.).

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 16 h

Sources & evidence

ORD record
ord-dcf5a5473dd648b9bb99595543bccb62
Source dataset
uspto-grants-2007_12
Patent number
US07307172B2

Reaction notes

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