反应详情

温度

150 °C

A solution of cyanomethylenetri-N-butylphosphorane (0.663 g, 2.75 mmol) in THF (1.5 mL) was added to a solution of ethyl(2S)-2-ethoxy-3-[4-(2-hydroxyethyl)phenyl]-propanoate (0.244 g, 0.92 mmol) and 4-hydroxyphenyl methanesulfonate (0.172 g, 0.92 mmol) in THF (1.5 mL). The reaction mixture was heated at 150° C. in a microwave oven for 10 minutes. The solvent was removed under reduced pressure. The crude product was purified by flash chromatography (silica, heptane/ethyl acetate 3:1 as the mobile phase) affording 0.167 g (42%) of the title compound.

1. customThe solvent was removed under reduced pressure
2. customThe crude product was purified by flash chromatography (silica, heptane/ethyl acetate 3:1 as the mobile phase)