Sodium Hydroxide → HCID 69410624, compound

HRID 970046Notes

Reaction equation

HRID 970046 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[C:7](/[CH:13]=[CH:14]/[C:15]1[CH:16]=[CH:17][C:18]3[CH:24]=[CH:23][C:22]4[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=4[CH:20]([S:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])[C:19]=3[CH:35]=1)[CH:6]=[CH:5]2.[OH-].[Na+:37]>O1CCCC1.CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[C:7](/[CH:13]=[CH:14]/[C:15]1[CH:16]=[CH:17][C:18]3[CH:24]=[CH:23][C:22]4[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=4[CH:20]([S:29][CH2:30][CH2:31][C:32]([O-:34])=[O:33])[C:19]=3[CH:35]=1)[CH:6]=[CH:5]2.[Na+:37]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 69409386HCID 69409386, compound

Product 1

HCID 69410624HCID 69410624, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-{[3-[(E)-2-(6,7-difluoroquinolin-2-yl)ethenyl]-5H-dibenzo[a,d]cyclohepten-5-yl]thio}propionic acid obtained in Example 4(a) was dissolved as such in a mixed solution of 10 ml of tetrahydrofuran and 20 ml of methanol, 0.35 ml (0.35 mmol) of an aqueous 1N sodium hydroxide solution was added to the solution and the mixture was stirred at room temperature for 1 hour.

Workup

  1. additionwas added to the solution

Sources & evidence

ORD record
ord-8fb6e2e7dce846b3ba0f7c2d4546e1e3
Source dataset
uspto-grants-2007_12
Patent number
US07309718B2

Reaction notes

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