HCID 22935209, compound → HCID 69410690, compound

HRID 970052Notes

Reaction equation

HRID 970052 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([OH:14])=O)=[CH:4][CH:3]=1>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:8][CH2:9][C:10]3[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[C:6]=2[CH:7]=1

Participants

3

Reactant 1

HCID 22935209HCID 22935209, compound

Product 1

HCID 69410690HCID 69410690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
170 °C

Procedure

To 25.8 g (80 mmol) of 2-[2-(4-bromophenyl)ethyl]-3-fluorobenzoic acid was added 550 g of polyphosphoric acid, and the mixture was stirred at 170° C. for 3 hours. After cooling the mixture to 80° C. by allowing to stand, water was added to the mixture and the resulting mixture was cooled to room temperature under stirring by allowing to stand.

Workup

  1. temperatureAfter cooling the mixture to 80° C.
  2. temperaturethe resulting mixture was cooled to room temperature
  3. stirringunder stirring

Sources & evidence

ORD record
ord-4314bf1376b248f39f3dba115ee6ea4e
Source dataset
uspto-grants-2007_12
Patent number
US07309718B2

Reaction notes

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