Sodium Hydroxide → HCID 11539546, compound

HRID 970090Notes

Reaction equation

HRID 970090 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH:4](Cl)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:8][CH:7]=1.[C:22]1([C:28]2[NH:32][C:31]([SH:33])=[N:30][CH:29]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[OH-].[Na+]>CO>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH:4]([S:33][C:31]2[NH:32][C:28]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:29][N:30]=2)[C:3]([O:2][CH3:1])=[O:21])=[CH:7][CH:8]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 10780869Methyl 3-(4-benzyloxyphenyl)-2-chloropropanoateHCID 178527853HCID 178527853, compound

Product 1

HCID 11539546HCID 11539546, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The solution of 0.3 g (0.001 mol) of methyl3-[4-(Benzyloxy)phenyl]-2-chloropropionate in methanol (2 ml) was added dropwise to the solution of 0.18 g (0.001 mol) 5-phenyl-1H-imidazol-2-thiol and 0.04 g (0.001 mol) of NaOH in methanol (3 ml). The solution then was heated at reflux for 5 h. The crude product obtained after removing the solvent was used without purification in the next step of the synthesis.

Workup

  1. temperatureThe solution then was heated
  2. temperatureat reflux for 5 h

Sources & evidence

ORD record
ord-35fa3076f9d24abf83425c9fcf2cf3a2
Source dataset
uspto-grants-2007_12
Patent number
US07309791B2

Reaction notes

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