Hydrochloric Acid → HCID 28804660, compound

HRID 970338Notes

Reaction equation

HRID 970338 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:17][OH:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=1)(C)(C)C.Cl>CO.O1CCOCC1>[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=1)[CH2:17][OH:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58666623468740-94-5

Product 1

HCID 28804660HCID 28804660, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (S)-[2-(3-bromo-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (400 mg, 1.21 mmol) in methanol (30 mL) was added 4 M HCl in dioxane (2 mL, excess). The reaction mixture was stirred at room temperature for 14 h. After concentration in vacuo, the residue was used for the next step without purification. LCMS (M+H)+ m/z 230 (t=0.78 min.) Procedure for the Preparation of 5-imidazol-1-yl-3-methyl-benzene-1,2-diamine

Workup

  1. concentrationAfter concentration in vacuo
  2. customthe residue was used for the next step without purification
  3. customLCMS (M+H)+ m/z 230 (t=0.78 min.) Procedure for the Preparation of 5-imidazol-1-yl-3-methyl-benzene-1,2-diamine

Sources & evidence

ORD record
ord-9f1d1b47e35f41c4a09556aa8a93eb07
Source dataset
uspto-grants-2007_12
Patent number
US07312215B2

Reaction notes

Loading…