HCID 58699966, compound → HCID 58699962, compound

HRID 970369Notes

Reaction equation

HRID 970369 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C@H:11]([NH:14][C@@H](C2C=CC=CC=2)C)[C@H:10]([C:23]([F:26])([F:25])[F:24])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C@H:11]([NH2:14])[C@H:10]([C:23]([F:26])([F:24])[F:25])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 58699966HCID 58699966, compound

Product 1

HCID 58699962HCID 58699962, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of (3R,4S)-4-((R)-1-phenylethylamino)-3-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester (2c) (1 equiv.) in ethanol in a Parr flask is added 10% Pd/C and the reaction is shaken under H2 (50 psi) for 6 hrs. The mixture is then filtered through celites and the filter pad is washed with EtOH. The filtrate is concentrated to give the title compound.

Workup

  1. filtrationThe mixture is then filtered through celites
  2. washthe filter pad is washed with EtOH
  3. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-fbd505d9f75349ca9db7013c99b5031a
Source dataset
uspto-grants-2007_12
Patent number
US07312212B2

Reaction notes

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