HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 4-Bromo-6,8-difluoroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | HCID 178516459 | HCID 178516459 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-6,8-difluoroquinoline | HCID 16111714 | — |
Reaction Steps
6,8-Difluoro-quinolin-4-ol (commercially available) (7.43 g) in DMF (200 mL) was treated with phosphorus tribromide (4.24 mL) by the method of Example (28a) to give a solid (9.03 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312212B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-062060a1c40d40188204dde64eaca325 |
| Source note | uspto-grants-2007_12 |