Phosphorus tribromide → 4-Bromo-6,8-difluoroquinoline

HRID 970390Notes

Reaction equation

HRID 970390 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([F:12])[CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2O.P(Br)(Br)[Br:15]>CN(C=O)C>[Br:15][C:5]1[C:4]2[C:9](=[C:10]([F:12])[CH:11]=[C:2]([F:1])[CH:3]=2)[N:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 178516459HCID 178516459, compound

Product 1

HCID 161117144-Bromo-6,8-difluoroquinoline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6,8-Difluoro-quinolin-4-ol (commercially available) (7.43 g) in DMF (200 mL) was treated with phosphorus tribromide (4.24 mL) by the method of Example (28a) to give a solid (9.03 g).

Sources & evidence

ORD record
ord-062060a1c40d40188204dde64eaca325
Source dataset
uspto-grants-2007_12
Patent number
US07312212B2

Reaction notes

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