Hydrochloric Acid → HCID 86760589, compound

HRID 970419Notes

Reaction equation

HRID 970419 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]([Br:18])=[CH:16][N:15]=[C:14]([Cl:19])[N:13]=1)(C)(C)C.Cl>C(#N)C.O1CCOCC1>[ClH:19].[Br:18][C:17]1[C:12]([NH:11][CH2:10][CH2:9][CH2:8][NH2:7])=[N:13][C:14]([Cl:19])=[N:15][CH:16]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59020397HCID 59020397, compound

Product 1

HCID 86760589HCID 86760589, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 5.0 g (13.7 mmol) of [3-(5-bromo-2-chloro-pyrimidin-4-ylamino)-propyl]-carbamic acid-tert-butyl-ester in 150 ml of acetonitrile is mixed with 25 ml of a 4 molar solution of hydrochloric acid in dioxane and stirred at room temperature. After 4 hours, the solvent is drawn off in a rotary evaporator, and the residue is dried in a drying oven. 4.1 g (13.7 mmol, corresponding to 100% of theory) of the product is obtained.

Workup

  1. customthe solvent is drawn off in a rotary evaporator
  2. customthe residue is dried in a drying oven
  3. custom4.1 g (13.7 mmol, corresponding to 100% of theory) of the product is obtained

Sources & evidence

ORD record
ord-3e7d0ba980094743ac91bad4b3025eba
Source dataset
uspto-grants-2007_12
Patent number
US07312225B2

Reaction notes

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