反应详情

125 mg (0.27 mmol) of 2-chloro-4-[3-(3-nitro-benzenesulfonylamino)-propylamino]-pyrimidine-5-carboxylic acid-tert-butylamide is mixed with 4 ml of thionyl chloride and stirred under reflux for 19 hours. The reaction mixture is concentrated by evaporation. It is mixed with water and toluene and evaporated to the dry state in a rotary evaporator. 110 mg (0.27 mmol, corresponding to 100% of theory) of the product is obtained.

1. temperatureunder reflux for 19 hours
2. concentrationThe reaction mixture is concentrated by evaporation
3. additionIt is mixed with water and toluene
4. customevaporated to the dry state in a rotary evaporator
5. custom110 mg (0.27 mmol, corresponding to 100% of theory) of the product is obtained