Thionyl Chloride → N-[3-(2-Chloro-5-cyano-pyrimidin-4-ylamino)-propyl]-3-nitro-benzenesulfonamide

Participants

Reaction Steps

125 mg (0.27 mmol) of 2-chloro-4-[3-(3-nitro-benzenesulfonylamino)-propylamino]-pyrimidine-5-carboxylic acid-tert-butylamide is mixed with 4 ml of thionyl chloride and stirred under reflux for 19 hours. The reaction mixture is concentrated by evaporation. It is mixed with water and toluene and evaporated to the dry state in a rotary evaporator. 110 mg (0.27 mmol, corresponding to 100% of theory) of the product is obtained.

Provenance & Evidence