反应详情

A solution of 212 mg (0.45 mmol) of (S)-{4-[2-(dimethylaminomethylene-sulfamoyl)-5-nitro-phenoxy]-1-hydroxymethyl-butyl}-carbamic acid-tert-butyl ester in 5 ml of acetonitrile is mixed at room temperature with 0.75 ml of a 4 molar solution of hydrochloric acid in dioxane. After 4 hours, the batch is concentrated by evaporation, and 2-(4-amino-5-hydroxy-pentyloxy)-N-dimethylaminomethylene-4-nitro-benzenesulfonamide is obtained in the form of hydrochloride.

1. concentrationthe batch is concentrated by evaporation