反应详情

A reaction mixture of 1.20 g (2.8 mmol) of [5-(5-bromo-2-chloro-pynmidin-4-ylamino)-pentyl]-carbamic acid-benzyl ester and 0.37 g (2.7 mmol) of 3-aminobenzoic acid in acetonitrile/water (8 ml/1.5 ml) is stirred under reflux for 20 hours. The reaction mixture is spun in, and the remaining residue is purified by chromatography (dichloromethane/methanol 9:1, Flashmaster II). 1.27 g (2.4 mmol, corresponding to 86% of theory) of the product is obtained.

1. temperatureunder reflux for 20 hours
2. customis purified by chromatography (dichloromethane/methanol 9:1, Flashmaster II)
3. custom1.27 g (2.4 mmol, corresponding to 86% of theory) of the product is obtained