Ammonia → HCID 11409828, compound

HRID 970635Notes

Reaction equation

HRID 970635 reaction equation
C[O:2][C:3](=O)[CH2:4][N:5]([S:22]([C:25]1[CH:34]=[CH:33][C:32]2[C:27](=[CH:28][CH:29]=[C:30]([Cl:35])[CH:31]=2)[CH:26]=1)(=[O:24])=[O:23])[C@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]2)[C:7]1=[O:21].[NH3:37]>CO>[Cl:35][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:22]([N:5]([C@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH:12]3[CH2:13][CH2:14][N:15]([CH:18]([CH3:20])[CH3:19])[CH2:16][CH2:17]3)[C:7]1=[O:21])[CH2:4][C:3]([NH2:37])=[O:2])(=[O:23])=[O:24])[CH:34]=[CH:33]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11237965HCID 11237965, compound2×

Product 1

HCID 11409828HCID 11409828, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-[(6-Chloro-naphthalene-2-sulfonyl)-(1′-isopropyl-2-oxo-[1,4′]bipiperidinyl-3-yl)-amino]-acetic acid methyl ester (the product obtained in Example 8) was dissolved in 2.0M NH3 in methanol (5.0 mL), and the mixture was stirred at room temperature for 48 hr. The solvent was removed. HPLC purification (10% to 100% acetonitrile/water) provided the title compound as a white solid. LC-MS found: (M+1)+=521.31.

Workup

  1. customThe solvent was removed
  2. customHPLC purification (10% to 100% acetonitrile/water)

Sources & evidence

ORD record
ord-b2e289510bde4b32adb259ed49040307
Source dataset
uspto-grants-2007_12
Patent number
US07312218B2

Reaction notes

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