反应详情

温度

0 °C

4-Phenoxymethylbenzoic acid 3 (3.424 g, 15.0 mmol) was dissolved in tetrahydrofuran (THF) (50 ml) and cooled to 0° C. A solution of borane in THF (33 ml, 33.0 mmol) was added dropwise at 0° C. The solution was then allowed to warm to room temperature and stir overnight. The mixture was then quenched with water, aqueous NaOH was added, and stirred for 30 min. The solution was then acidified with dilute HCl and extracted. The extracts were dried, concentrated, and purified by chromatography to give about 2.9 g of crystalline 4-phenoxymethylphenylmethanol 4.

1. temperatureto warm to room temperature
2. customThe mixture was then quenched with water, aqueous NaOH
3. additionwas added
4. stirringstirred for 30 min
5. extractionextracted
6. customThe extracts were dried
7. concentrationconcentrated
8. custompurified by chromatography