1-bromo-3-isopropyl-2-hydroxybenzene → HCID 10125288, compound

HRID 970829Notes

Reaction equation

HRID 970829 reaction equation
Br[C:2]1[C:7]([OH:8])=[C:6]([CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][CH:3]=1.[C:12]([C:16](C(O[Na])=O)([F:18])[F:17])([F:15])([F:14])[F:13]>[Cu]I>[F:17][C:16]([F:18])([C:2]1[C:7]([OH:8])=[C:6]([CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][CH:3]=1)[C:12]([F:15])([F:14])[F:13]

Participants

4

Reactant 2

HCID 146639651-bromo-3-isopropyl-2-hydroxybenzeneHCID 178526066HCID 178526066, compound

Product 1

HCID 10125288HCID 10125288, compound

Reagents, catalysts & solvents 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Catalyst

Procedure

6-Bromo-2-isopropylphenol, made as described in Example 2, was reacted with CF3CF2COONa in the presence of CuI (Freskos J N, Synth Comm 18:965-972, 1988). This reaction resulted in the synthesis of 6-pentafluoroethyl-2-isopropylphenol.

Sources & evidence

ORD record
ord-f89f4cc8f0b846209964c5e5d63122b3
Source dataset
uspto-grants-2007_12
Patent number
US07312250B2

Reaction notes

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