反应详情

800 mg (2.2 mmol) of dimethyl 4-[3-(3-ethyl-4-hydroxyphenyl)propyl}phthalate are dissolved in 40 ml of 2-butanone. 340 mg (2.5 mmol) of potassium carbonate and 330 μl (2.5 mmol) of 1-bromopinacolone are added. The reaction medium is heated under reflux for 8 hours, and is then filtered on celite. The residue obtained is purified by chromatography on a silica column (eluent ethyl acetate 20/heptane 80). A colorless oil is obtained (m=920 mg; y=90%).

1. temperatureThe reaction medium is heated
2. temperatureunder reflux for 8 hours
3. filtrationis then filtered on celite
4. customThe residue obtained
5. customis purified by chromatography on a silica column (eluent ethyl acetate 20/heptane 80)
6. customA colorless oil is obtained (m=920 mg; y=90%)