Methanol → HCID 22601390, compound

HRID 970903Notes

Reaction equation

HRID 970903 reaction equation
[C:1]1([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14](O)=[O:15])(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B.C1COCC1.CO>C1COCC1>[OH:15][CH2:14][C:13]1[CH:12]=[C:11]([S:8]([NH:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)(=[O:10])=[O:9])[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 7593393-(Phenylsulfamoyl)benzoic acidHCID 2723981Borane;tetrahydrofuran

Product 1

HCID 22601390HCID 22601390, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To solution of 3-Phenylsulfamoyl-benzoic acid (380 mg, 1.36 mmol) in THF (10 ml) was added BH3.THF (1M, 5.4 ml, 5.4 mmol) dropwise. After the addition, the reaction mixture was allowed to stir for 3 d at room temperature. Methanol was added to the reaction and the mixture concentrated in vacuo (5×). This compound was used in the next step without further purification.

Workup

  1. additionAfter the addition
  2. concentrationthe mixture concentrated in vacuo (5×)
  3. customThis compound was used in the next step without further purification

Sources & evidence

ORD record
ord-668321fb416047299089ec0f9bf1348f
Source dataset
uspto-grants-2007_12
Patent number
US07312234B2

Reaction notes

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