Ethanol → 6,8-Dibromoimidazo[1,2-a]pyrazine

HRID 971067Notes

Reaction equation

HRID 971067 reaction equation
[Br:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[CH2:10](O)[CH3:11]>>[Br:8][C:6]1[N:7]=[C:2]([Br:1])[C:3]2[N:4]([CH:10]=[CH:11][N:9]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 6200042-Amino-3,5-dibromopyrazine

Product 1

HCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Procedure

A solution of 1.00 eq. of 3,5-dibromo-2-aminopyrazine 1 in ethanol is treated with 2.00 eq. of α-bromo-aldehyde 2 at RT and heated for 48 hr. The solvent is removed under reduced pressure and the residue is triturated with diethyl ether and filtered to give the HBr salt 3.

Workup

  1. temperatureheated for 48 hr
  2. customThe solvent is removed under reduced pressure
  3. customthe residue is triturated with diethyl ether
  4. filtrationfiltered

Sources & evidence

ORD record
ord-14e1d1590be74f4a9d644d76ab4ff773
Source dataset
uspto-grants-2007_12
Patent number
US07312341B2

Reaction notes

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