HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 971074Generated: October 26, 2026
Ethyl 3-bromoindole-7-carboxylate → 3-Cyano-1H-indole-7-carboxylic acid
https://huagongshe.com/reaction/971074
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 3-bromoindole-7-carboxylate | HCID 17933196 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-Cyano-1H-indole-7-carboxylic acid | HCID 11367431 | — |
Reaction Steps
7 g of ethyl 3-bromoindole-7-carboxylate are dissolved in 70 g of NMP, and 4 g of CuCN are added. The mixture is heated to 100-140° C. with stirring. After 3 hours, the mixture is subjected to conventional work-up, giving 3-cyanoindole-7-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07312342B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-e3bf35874ded474188a9606433d30327 |
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| Source note | uspto-grants-2007_12 |
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