HRID971074

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17933196

未命名化合物

HCID178418546

未命名化合物

PRODUCTS

生成物

HCID11367431

3-Cyano-1H-indole-7-carboxylic acid

C10H6N2O2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

7 g of ethyl 3-bromoindole-7-carboxylate are dissolved in 70 g of NMP, and 4 g of CuCN are added. The mixture is heated to 100-140° C. with stirring. After 3 hours, the mixture is subjected to conventional work-up, giving 3-cyanoindole-7-carboxylic acid.