反应详情

温度

2.5 °C

A mixture of N-(2-butyl-5-benzofuranyl)acetamide [10a] (1.16 g, 5.0 mmol) and 15% hydrochloric acid (10 mL) was stirred overnight under reflux conditions and 2 hours at 0-5° C. The precipitated crystals were filtered off, washed on the filter with cold water and ethyl acetate and dried under reduced pressure at 50° C. (water bath) to a constant weight to give 1.00 g (88.6%) of 2-butyl-5-benzofuranamine hydrochloride [12a] as off-white crystalls with mp 189-192° C. (with decomposition).

1. filtrationThe precipitated crystals were filtered off
2. washwashed on the
3. filtrationfilter with cold water and ethyl acetate
4. dry with materialdried under reduced pressure at 50° C. (water bath) to a constant weight