反应详情

温度

0 °C

To a solution of 2-(4-chlorocarbonyl-phenyl)-2-methyl-propionic acid methyl ester (240.0 mg, 1.0 mmol) in CH2Cl2 at 0° C. was added TEA (3.0 mmol) followed by addition of 2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide (281 mg, 1.0 mmol) and DMAP (cat. 10 mg). The resulted mixture was stirred at 0° C. for 1 hr and rt over night. Solvent was evaporated and HPLC purification gave 2{4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propionic acid methyl ester as white solid. MS found: (M+1)+=486.2.

1. customSolvent was evaporated
2. customHPLC purification