反应详情

温度

60 °C

To a solution of 2{4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propionic acid methyl ester (485.0 mg, 1 mmol) in THF was added LiBH4 (2.0 ml, 2.0 M solution in THF). The mixture was stirred at 60° C. over night. The reaction mixture was cooled, and quenched with sat'd NH4Cl. HPLC purification gave 2{4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propyl alcohol as white solid. MS found: (M+1)+=457.9.

1. temperatureThe reaction mixture was cooled
2. customquenched with sat'd NH4Cl
3. customHPLC purification