2,3-Dichloropyridine → HCID 12004365, compound

HRID 971208Notes

Reaction equation

C(N(C(C)C)CC)(C)C.[C:10]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]2[C:22]3[CH2:37][CH2:36][NH:35][CH2:34][C:23]=3[N:24]=[C:25]([CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[N:26]=2)=[CH:16][CH:15]=1)([CH3:13])([CH3:12])[CH3:11].Cl[C:39]1[C:44]([Cl:45])=[CH:43][CH:42]=[CH:41][N:40]=1>O1CCOCC1.C(N(CC)C(=O)C)C>[C:10]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]2[C:22]3[CH2:37][CH2:36][N:35]([C:39]4[C:44]([Cl:45])=[CH:43][CH:42]=[CH:41][N:40]=4)[CH2:34][C:23]=3[N:24]=[C:25]([CH2:27][N:28]3[CH2:29][CH2:30][O:31][CH2:32][CH2:33]3)[N:26]=2)=[CH:16][CH:15]=1)([CH3:13])([CH3:11])[CH3:12]

Participants

Conditions

Temperature: 180 °C

Procedure

A mixture of diisopropylethylamine (35 mg, 0.27 mmol), N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(morpholinomethyl)pyrido[3,4-d]pyrimidin-4-amine (70 mg, 0.18 mmol) and 2,3-dichloropyridine (54 mg, 0.36 mmol) in dioxane (2 mL) and N,N-diethylacetamide (0.2 mL) was heated via microwave in a sealed tube at 180° C. for 10 hr. Solvent was removed in vacuo and residue was purified by column chromatography, product was obtained as a light yellow foam (27 mg).

Workup

customSolvent was removed in vacuo and residue
customwas purified by column chromatography

Sources & evidence

ORD record: ord-8814e97aa1f74aea97ce6403c95f1b9b
Source dataset: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07312330B2

Reaction notes

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