2,3-Dichloropyridine → 7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one
Reaction equation
[N:1]1[C:6]2[CH2:7][NH:8][CH2:9][CH2:10][C:5]=2[C:4](=[O:11])[NH:3][CH:2]=1.CCN(C(C)C)C(C)C.Cl[C:22]1[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][N:23]=1>O1CCOCC1.CC(N(C)C)=O>[Cl:28][C:27]1[C:22]([N:8]2[CH2:9][CH2:10][C:5]3[C:4](=[O:11])[NH:3][CH:2]=[N:1][C:6]=3[CH2:7]2)=[N:23][CH:24]=[CH:25][CH:26]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
5,6,7,8-Tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (1.5 g, 10 mmol) was dissolved in a mixture of dioxane-dimethylacetamide (2 ml, 3:1) and 2,3-dichloropyridine was added (1.5 g, 10 mmol), followed by DIEA (1.7 ml; 10 mmol). The mixture was heated at 150° C. for 2 hours in a microwave (Personal Chemistry, Smith Creator). The solvents were evaporated and the residue was dissolved in a 3:1 mixture of chloroform-isopropanol and washed with water. The organic layer washed with brine, dried over soldium sulphate, filtered and evaporated to give a yellow solid (3 g). The crude material was used for the subsequent step.
Workup
- additionwas added (1.5 g, 10 mmol)
- customThe solvents were evaporated
- dissolutionthe residue was dissolved in a 3:1 mixture of chloroform-isopropanol
- washwashed with water
- washThe organic layer washed with brine
- customdried
- filtrationfiltered
- customevaporated
Sources & evidence
- ORD record
- ord-eee96b2cffb14e46afb2a4322d035885
- Source dataset
- uspto-grants-2007_12
- Patent number
- US07312330B2
Reaction notes
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