HCID 59021521, compound → HCID 59021525, compound

Participants

Reaction Steps

7-Benzyl-N-(4-(trifluoromethanesulphonyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.15 g, 0.33 mmol) was dissolved in methanol (25 mL) and palladium hydroxide was added (0.15 g, 20% wt). The mixture was shaken on a Parr Shaker under H2 (g) atmosphere (60 PSI) for 24 hours. The mixture was filtered through celite and evaporated to give 91 mg of material as a white solid (77%), which was used directly in the next step.

Provenance & Evidence