HCID 59021521, compound → HCID 59021525, compound

HRID 971222Notes

Reaction equation

HRID 971222 reaction equation
C([N:8]1[CH2:17][CH2:16][C:15]2[C:14]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26])=[CH:21][CH:20]=3)=[N:13][CH:12]=[N:11][C:10]=2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[F:31][C:28]([F:29])([F:30])[S:25]([C:22]1[CH:23]=[CH:24][C:19]([NH:18][C:14]2[C:15]3[CH2:16][CH2:17][NH:8][CH2:9][C:10]=3[N:11]=[CH:12][N:13]=2)=[CH:20][CH:21]=1)(=[O:26])=[O:27]

Participants

4

Reactant 1

HCID 59021521HCID 59021521, compound

Product 1

HCID 59021525HCID 59021525, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

7-Benzyl-N-(4-(trifluoromethanesulphonyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.15 g, 0.33 mmol) was dissolved in methanol (25 mL) and palladium hydroxide was added (0.15 g, 20% wt). The mixture was shaken on a Parr Shaker under H2 (g) atmosphere (60 PSI) for 24 hours. The mixture was filtered through celite and evaporated to give 91 mg of material as a white solid (77%), which was used directly in the next step.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customevaporated

Sources & evidence

ORD record
ord-d7c5a3dbd6fc4625a52a6613a296c9e2
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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