Sodium Iodide → 7-benzyl-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine

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Reaction Conditions

Reaction Steps

Sodium iodide (3.9 g, 26 mmol) and hydriodic acid (10 mL, 47% aqueous solution) were added to a mixture of 7-benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidine (8.0 g, 26 mmol) and 4-aminobenzotrifluoride (5.06 g, 0.031 mol) in dioxane (100 mL) and the reaction mixture was stirred at 100° C. overnight. Solid thus formed was filtered out, washed with ethyl acetate and diethyl ether and dried in vacuo. Product was obtained as white needle solid (8.2 g).

Provenance & Evidence