反应详情

温度

100 °C

Sodium iodide (3.9 g, 26 mmol) and hydriodic acid (10 mL, 47% aqueous solution) were added to a mixture of 7-benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidine (8.0 g, 26 mmol) and 4-aminobenzotrifluoride (5.06 g, 0.031 mol) in dioxane (100 mL) and the reaction mixture was stirred at 100° C. overnight. Solid thus formed was filtered out, washed with ethyl acetate and diethyl ether and dried in vacuo. Product was obtained as white needle solid (8.2 g).

1. customSolid thus formed
2. filtrationwas filtered out
3. washwashed with ethyl acetate and diethyl ether
4. customdried in vacuo