HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethyl-6-nitro-1,3-dihydro-2H-indol-2-one → 6-Amino-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethyl-6-nitro-1,3-dihydro-2H-indol-2-one | HCID 13589227 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Amino-3,3-dimethyl-1,3-dihydro-2H-indol-2-one | HCID 13589229 | 99.3% |
Reaction Steps
A mixture of 3,3-dimethyl-6-nitroindolin-2-one (500 mg, 2.4 mmol), 10% Pd—C (100 mg), and MeOH (100 mL) was stirred under H2 (1 atm) for 3 h. After that the catalyst was filtered off and the filtrate was concentrated to give an off-white solid (420 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312330B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-7821239df1d54127a3fe52258941be94 |
| Source note | uspto-grants-2007_12 |