HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 971259Generated: October 30, 2026
Hydrochloric Acid → 7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(3,3-dimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/971259
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 12004101 | HCID 12004101 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(3,3-dimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine | HCID 12004102 | 124.1% |
Reaction Steps
A mixture of compound of Example 68 (40 mg), EtOH (5 mL), and 5 N HCl (1.0 mL) was stirred at 55° C. overnight. After cooling, the solvent was removed in vacuo to give a yellow solid (45 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07312330B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-7460a306e4b5453db3f4ae1ef729df99 |
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| Source note | uspto-grants-2007_12 |
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