Hydrochloric Acid → 7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(3,3-dimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine

HRID 971259Notes

Reaction equation

HRID 971259 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:15]3[C:14]([NH:18][C:19]4[CH:27]=[C:26]5[C:22]([C:23]([CH3:32])([CH3:31])[CH2:24][N:25]5C(=O)C)=[CH:21][CH:20]=4)=[N:13][CH:12]=[N:11][C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl>CCO>[Cl:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:15]3[C:14]([NH:18][C:19]4[CH:27]=[C:26]5[C:22]([C:23]([CH3:32])([CH3:31])[CH2:24][NH:25]5)=[CH:21][CH:20]=4)=[N:13][CH:12]=[N:11][C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12004101HCID 12004101, compound

Product 1

HCID 120041027-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(3,3-dimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amineYield 124.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
55 °C

Procedure

A mixture of compound of Example 68 (40 mg), EtOH (5 mL), and 5 N HCl (1.0 mL) was stirred at 55° C. overnight. After cooling, the solvent was removed in vacuo to give a yellow solid (45 mg).

Workup

  1. temperatureAfter cooling
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-7460a306e4b5453db3f4ae1ef729df99
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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