Hydrochloric Acid → HCID 21313672, compound

HRID 971382Notes

Reaction equation

HRID 971382 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[S:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1)=[O:7].Cl.[CH3:23]O>>[F:21][C:2]([F:1])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[S:12][C:11]([CH2:13][C:14]([O:16][CH3:23])=[O:15])=[CH:10][CH:9]=1)=[O:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21313682HCID 21313682, compound

Product 1

HCID 21313672HCID 21313672, compound

Procedure

1.60 gm of 5-(m-trifluoromethylbenzoyl)-thiophene-2-acetic acid were dissolved in 30 cc of methanol and the solution was saturated with gaseous hydrochloric acid and refluxed for 1 hour. The solvent was then distilled off under reduced pressure and the residue was taken up in a minimum of isopropyl ether. An equal volume of petroleum ether was added to the solution. Crystallization was induced by scratching and the solution was iced for 12 hours. The crystals were separated, washed with petroleum ether and dried to obtain 1.35 gm of methyl 5-(m-trifluoromethyl benzoyl)-thiophene-2-acetate.

Workup

  1. temperaturerefluxed for 1 hour
  2. distillationThe solvent was then distilled off under reduced pressure
  3. additionAn equal volume of petroleum ether was added to the solution
  4. customCrystallization
  5. customThe crystals were separated
  6. washwashed with petroleum ether
  7. customdried

Sources & evidence

ORD record
ord-ba4e55b5c5bd4f4fb03df78737d46c9e
Source dataset
uspto-grants-1979_07
Patent number
US04159986

Reaction notes

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