HCID 21313745, compound → HCID 21313752, compound

HRID 971394Notes

Reaction equation

C([NH:4][C:5]1[C:6](I)=[C:7]([C:11](I)=[C:12]([NH:15][C:16](=[O:22])[CH2:17][C:18]([OH:21])([OH:20])[OH:19])[C:13]=1I)[C:8]([OH:10])=[O:9])(=O)C.[N+](C1C(NC(=O)C(CO)(CO)CO)=C(C=CC=1)C(O)=O)([O-])=O>>[NH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([NH:15][C:16](=[O:22])[CH2:17][C:18]([OH:21])([OH:20])[OH:19])[CH:13]=1)[C:8]([OH:10])=[O:9]

Participants

Reactant 2

HCID 21313745HCID 21313745, compound

HCID 53754534HCID 53754534, compound

Product 1

HCID 21313752HCID 21313752, compound

Procedure

In the preparation of the 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamido-benzoic acid of the invention, 3-nitro-trishydroxymethylacetamido-benzoic acid is reduced to form 3-amino-5-trishydroxymethylacetamido-benzoic acid. The latter is then iodinated to form 3-amino-2,4,6-triiodo-5-trishydroxymethylacetamidobenzoic acid, after which the 3-amino compound is acylated to form the desired 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamido-benzoic acid.

Sources & evidence

ORD record: ord-5b1331870a8040c7bb5bfa396b69d2b5
Source dataset: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04160015

Reaction notes

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