Hydrochloric Acid → HCID 178485015, compound

Participants

Reaction Steps

Dry hydrogen chloride gas was passed into a solution of N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-thiourea (73.2 g) in methanol (600 ml) and the mixture was refluxed for 5 hours. Concentration and re-evaporation with isopropyl alcohol afforded a crystalline solid which was recrystallised from isopropyl alcohol-ether to give N,S-dimethyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-isothiourea dihydrochloride (96.2 g) m.p. 191°-192°. (isopropyl alcohol-ether).

Provenance & Evidence