Hydrochloric Acid → HCID 178485015, compound

HRID 971431Notes

Reaction equation

HRID 971431 reaction equation
[ClH:1].[CH3:2][NH:3][C:4]([NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])=[S:5].[CH3:17]O>>[ClH:1].[ClH:1].[CH3:2][NH:3][C:4](=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])[S:5][CH3:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178486120HCID 178486120, compound

Product 1

HCID 178485015HCID 178485015, compound

Procedure

Dry hydrogen chloride gas was passed into a solution of N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-thiourea (73.2 g) in methanol (600 ml) and the mixture was refluxed for 5 hours. Concentration and re-evaporation with isopropyl alcohol afforded a crystalline solid which was recrystallised from isopropyl alcohol-ether to give N,S-dimethyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-isothiourea dihydrochloride (96.2 g) m.p. 191°-192°. (isopropyl alcohol-ether).

Workup

  1. temperaturethe mixture was refluxed for 5 hours
  2. concentrationConcentration and re-evaporation with isopropyl alcohol
  3. customafforded a crystalline solid which
  4. customwas recrystallised from isopropyl alcohol-ether

Sources & evidence

ORD record
ord-b263f65426974fc79c01ad88529e3aca
Source dataset
uspto-grants-1979_07
Patent number
US04160030

Reaction notes

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