HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl formate → 17beta-Hydroxy-2-hydroxymethylene-6alpha-methylandrost-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl formate | HCID 7865 | — |
| Reactant | 6alpha-Methyltestosterone | HCID 236417 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4,17alpha-Dimethyl-2-hydroxymethylene Testosterone | HCID 57349609 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 17beta-Hydroxy-2-hydroxymethylene-6alpha-methylandrost-4-en-3-one | HCID 70603326 | — |
Reaction Steps
17β-Hydroxy-2-hydroxymethylene-6α-methylandrost-4-en-3-one was prepared from 286 g. of 17β-hydroxy-6α-methylandrost-4-en-3-one (6α-methyltestosterone), 410 ml. of methyl formate, 140 g. of sodium methoxide, 40 ml. of methanol and 3 l. of tetrahydrofuran according to the procedure of Example 1, part (c). The total product, obtained nearly quantitative yield as an amber glass was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160027 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-8999705e8090481b8976251e836de4c8 |
| Source note | uspto-grants-1979_07 |