反应详情

Sodium hydroxide (2 g) in water (35 ml) was added to a stirred mixture of acetone (9.7 g) and ethanol (20 ml) cooled in a water bath. 4-Fluorocinnamaldehyde (5 g) was added dropwise to the stirred solution such that the temperature did not exceed 25°. The mixture was stirred at room temperature for 5 min, diluted with water (250 ml), adjusted to pH 1 with 5 M hydrochloric acid and extracted with ethyl acetate (3×100 ml). The combined extracts were washed with brine (1×100 ml), dried (MgSO4) and evaporated to give an orange oil (6.1 g) which was used crude in the next stage.

1. temperaturecooled in a water bath
2. customdid not exceed 25°
3. extractionextracted with ethyl acetate (3×100 ml)
4. washThe combined extracts were washed with brine (1×100 ml)
5. dry with materialdried (MgSO4)
6. customevaporated