Water → HCID 12814764, compound

Participants

Reaction Steps

A mixture of sodium hydroxide (4.2 g), water (4.2 g), benzene (6 ml) and tetrabutylammonium iodide (0.45 g) was heated to 70°. A solution of isobutyraldehyde (8.65 g) and 4-fluorobenzyl chloride (13.01 g) was dripped into the mixture which was stirred at 70° for 5 hr. The product was extracted into ether, the solution was dried (MgSO4) and evaporated to give an oil b.p. 80°/1.0 mm (15.30 g).

Provenance & Evidence