Water → HCID 12814764, compound

HRID 971441Notes

Reaction equation

HRID 971441 reaction equation
[OH-].[Na+].O.[CH:4](=[O:8])[CH:5]([CH3:7])[CH3:6].[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Cl)=[CH:12][CH:11]=1>[I-].C([N+](CCCC)(CCCC)CCCC)CCC.C1C=CC=CC=1>[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][C:5]([CH3:7])([CH3:6])[CH:4]=[O:8])=[CH:12][CH:11]=1

Participants

7

Reactant 4

HCID 962WaterHCID 6561IsobutyraldehydeHCID 96024-Fluorobenzyl chlorideHCID 14798Sodium Hydroxide

Product 1

HCID 12814764HCID 12814764, compound

Reagents, catalysts & solvents 2

HCID 67553Tetrabutylammonium IodideCatalystHCID 241BenzeneSolvent

Procedure

A mixture of sodium hydroxide (4.2 g), water (4.2 g), benzene (6 ml) and tetrabutylammonium iodide (0.45 g) was heated to 70°. A solution of isobutyraldehyde (8.65 g) and 4-fluorobenzyl chloride (13.01 g) was dripped into the mixture which was stirred at 70° for 5 hr. The product was extracted into ether, the solution was dried (MgSO4) and evaporated to give an oil b.p. 80°/1.0 mm (15.30 g).

Workup

  1. temperaturewas heated to 70°
  2. extractionThe product was extracted into ether
  3. dry with materialthe solution was dried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-afacad740c6c440385bd01ccf13d598f
Source dataset
uspto-grants-1979_07
Patent number
US04160036

Reaction notes

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