Quinoline, 5,6,7,8-tetrahydro-3,4-dimethyl- → HCID 178506823, compound

HRID 971498Notes

Reaction equation

[CH2:1]([Li:5])[CH2:2][CH2:3][CH3:4].[CH3:6][C:7]1[CH:8]=[N:9][C:10]2CCCC[C:15]=2[C:16]=1[CH3:17]>>[Li:5][CH:1]1[C:10]2[N:9]=[CH:8][C:7]([CH3:6])=[C:16]([CH3:17])[C:15]=2[CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 12278208Quinoline, 5,6,7,8-tetrahydro-3,4-dimethyl-

HCID 178418339Butyllithium

Product 1

HCID 178506823HCID 178506823, compound

Procedure

By the method described in Example 7 using n-butyl lithium solution (9% w/v, 25 ml, 0.034 mol), and 3,4-dimethyl-5,6,7,8-tetrahydroquinoline-(5.65 g, 0.034 mol) the title compound is prepared and converted to methyl 3,4-dimethyl-5,6,7,8-tetrahydroquinoline-8-carboxylate which is then converted to the corresponding 8-thioamide by the procedure of U.S. Ser. No. 460,265.

Sources & evidence

ORD record: ord-e0808a7921684d849aba7c82fbd300da
Source dataset: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04160094

Reaction notes

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