Hydrochloric Acid → Glycine, N-(N-L-methionyl-L-leucyl)-

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Reaction Steps

3 g of the tripeptide derivative obtained under (7) are mixed with 60 ml of 0.4 N HCl in ethyl acetate and the reaction mixture is left for 90 minutes at 25° C. It is then evaporated to dryness and the residue (H-Met-Leu-Gly-OMe hydrochloride) is dried for 24 hours over sodium hydroxide at 0.01 mm Hg.

Provenance & Evidence