Hydrochloric Acid → Glycine, N-(N-L-methionyl-L-leucyl)-

HRID 971539Notes

Reaction equation

HRID 971539 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][CH2:18][C:19]([O:21]C)=[O:20])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH2:4][S:5][CH3:6].Cl>C(OCC)(=O)C>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][CH2:18][C:19]([OH:21])=[O:20])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH2:4][S:5][CH3:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131711561HCID 131711561, compound

Product 1

HCID 7020116Glycine, N-(N-L-methionyl-L-leucyl)-

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3 g of the tripeptide derivative obtained under (7) are mixed with 60 ml of 0.4 N HCl in ethyl acetate and the reaction mixture is left for 90 minutes at 25° C. It is then evaporated to dryness and the residue (H-Met-Leu-Gly-OMe hydrochloride) is dried for 24 hours over sodium hydroxide at 0.01 mm Hg.

Workup

  1. customIt is then evaporated to dryness
  2. dry with materialthe residue (H-Met-Leu-Gly-OMe hydrochloride) is dried for 24 hours over sodium hydroxide at 0.01 mm Hg

Sources & evidence

ORD record
ord-52be3fccbf924e8881f514da9fa03e76
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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