HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Z-Gln-Asp(OtBu)-Phe-OCH3
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Z-Gln-ONp | HCID 111333 | — |
| Reactant | H-Asp(OtBu)-Phe-OCH3.HCl | HCID 131711563 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Gln-Asp(OtBu)-Phe-OCH3 | HCID 131711562 | — |
Reaction Steps
550 mg of H-Asp(OtBu)-Phe-OCH3.HCl together with 574 mg of Z-Gln-ONP are dissolved in 2.5 ml of absolute N,N-dimethylformamide and stirred with 0.20 ml of triethylamine for 15 hours at 30°-33° C. bath temperature. Thereafter the product is extracted by shaking with a large amount of ethyl acetate as described under 19 and the solution is dried and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04159981 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-f017a377cb684d529119602f821e0abc |
| Source note | uspto-grants-1979_07 |